You are working as a scientist in an antibody-design group at a biologics company. Based on your knowledge of antibodies, which region(s) on which antibody type should you target for your design efforts to develop new antigen-binding capabilities in soluble antibodies?
A) IgG antibodies, variable light and variable heavy chain regions
B) IgE antibodies, constant light and variable heavy chain regions
C) IgG antibodies, variable heavy chain regions only
D) IgD antibodies, variable light and variable heavy chain regions
E) IgA antibodies, constant light and constant heavy chain regions

Question

Quizplus · Accepted Answer

IgG antibodies have the highest binding affinity and specificity and are the most commonly used antibodies in biologics. The variable light and variable heavy chain regions on IgG antibodies are responsible for antigen binding, so targeting these regions would be the best choice for developing new antigen-binding capabilities.

You Are Working as a Scientist in an Antibody-Design Group