Sometimes the difference in (standard) free-energy content, $\Delta$G'°, between a substrate S and a product P is very large, yet the rate of chemical conversion, S $\rightarrow$ P, is quite slow. Why?

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The Answer of Sometimes the difference in (standard) free-energy content, $\Delta$G'°, between a substrate S and a product P is very large, yet the rate of chemical conversion, S $\rightarrow$ P, is quite slow. Why?

Sometimes the Difference in (Standard) Free-Energy Content Δ\DeltaΔ G'°, Between a Substrate S and a Product P Is

Sometimes the Difference in (Standard) Free-Energy Content $\Delta$ G'°, Between a Substrate S and a Product P Is