Which sequence is the CORRECT one for leukocyte extravasion in the inflammatory response?
A) integrin binding $\rightarrow$ selectin binding $\rightarrow$adhesion $\rightarrow$ arrest $\rightarrow$ extravasion
B) adhesion $\rightarrow$ integrin binding $\rightarrow$ selectin binding$\rightarrow$ arrest $\rightarrow$extravasion
C) selectin binding $\rightarrow$integrin binding $\rightarrow$ adhesion $\rightarrow$ arrest $\rightarrow$ extravasion
D) integrin binding $\rightarrow$ adhesion $\rightarrow$selectin binding $\rightarrow$ arrest $\rightarrow$ extravasion
E) selectin binding $\rightarrow$ adhesion $\rightarrow$ integrin binding $\rightarrow$arrest $\rightarrow$extravasion

Question

Quizplus · Accepted Answer

The correct sequence for leukocyte extravasation during the inflammatory response starts with selectin binding, which mediates the initial weak adhesion and rolling of leukocytes along the vessel wall. This is followed by integrin binding, which strengthens the adhesion. Next, adhesion molecules facilitate the firm attachment of leukocytes to the endothelium (arrest), and finally, the leukocytes extravasate through the vessel wall into the tissue.

Which Sequence Is the CORRECT One for Leukocyte Extravasion in the Inflammatory