Two proteins interact to form a multimeric complex. When one of the proteins is mutated, there is a substantial loss of functional activity in the multimeric protein. This type of mutation is classified as __________.
A)amorphic
B)hypomorphic
C)hypermorphic
D)neomorphic
E)dominant negative

Question

Quizplus · Accepted Answer

This type of mutation is classified as dominant negative, which means that the mutated protein interferes with the activity of the non-mutated protein, leading to a loss of overall function in the multimeric protein.

Two Proteins Interact to Form a Multimeric Complex