After analysis of 100 pedigrees, the Z_max from the analysis of linkage between a disease gene D and the DNA marker P was found to be 3.5 at θ = 0.25. Which of the following is the best interpretation of these results? A)No conclusion can be made regarding linkage of D and P. B)The evidence supports linkage of D and P at 25 cM. C)The evidence supports linkage of D and P at 2.5 cM. D)The evidence supports linkage of D and P at 0.25 cM. E)The evidence indicates that D and P are not linked.

Question

Quizplus · Accepted Answer

The Z_max score of 3.5 indicates that there is evidence supporting linkage between the disease gene D and the DNA marker P. The value of θ at which this evidence was observed is 0.25, which corresponds to a distance of 25 cM between D and P on the chromosome. Therefore, the best interpretation of these results is that there is evidence supporting linkage of D and P at 25 cM.

After Analysis of 100 Pedigrees, the Zmax from the Analysis

After Analysis of 100 Pedigrees, the Z_max from the Analysis