Until recently, only apolipoprotein E (APOE)polymorphisms have been found to correlate with late-onset (nonfamilial)Alzheimer disease (AD); however, these account for less than 50% of the V_G. New GWA studies have found a chromosome 12 risk locus. What method will likely be used by AD researchers going forward? A)assessment of chromosome 12 for areas of linkage disequilibrium for AD B)association of APOE alleles with chromosome 12 SNPs C)sequencing of candidate genes on chromosome 12 and search for sequence similarity D)genotyping of a large cohort of AD patients and matched controls using a microchip E)analysis of genotypes of a large number of AD patients who have none of the expected APOE alleles

Question

Quizplus · Accepted Answer

Genotyping a large cohort of AD patients and matched controls using a microchip is likely to be the method used by AD researchers going forward. This approach allows for the identification of genetic variants that are associated with AD and are not limited to a specific candidate gene or region. It also allows for the identification of rare variants that may confer a high risk for AD.

Until Recently, Only Apolipoprotein E (APOE)polymorphisms Have Been Found to Correlate