Which of the following is part of the mechanism for epigenetic regulation of the Igf-2 gene
A) Methylation of the H19 locus
B) Methylation of the ICR and DMR domains
C) Binding of CTC factors to methylated sequences
D) Answers B and C are correct
E) Answers A and C are correct

Question

Quizplus · Accepted Answer

Epigenetic regulation of the Igf-2 gene involves methylation of the ICR (imprinting control region) and DMR (differentially methylated region) domains, which affects the binding of transcription factors. Additionally, CTCF (CCCTC-binding factor) proteins bind to the methylated sequences and further regulate the gene expression. Methylation of the H19 locus is also involved in the regulation of the Igf-2 gene, but this is not the mechanism for epigenetic regulation. Therefore, answer option D, which includes both correct statements, is the best choice.

Which of the Following Is Part of the Mechanism for Epigenetic