The enzyme phosphofructokinase (PFK) catalyses a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Given its critical role in glycolysis, which of the following conditions would be a likely consequence for dogs afflicted with this disorder?
A) They would die as embryos.
B) They would have elevated blood-glucose levels, which may result in a high incidence of diabetes.
C) They would be lethargic and readily tire from exercise.
D) They would carry out elevated levels of oxidative phosphorylation.

Question

Quizplus · Accepted Answer

Canine PFK deficiency would result in a decreased ability to generate ATP through glycolysis. This means that affected dogs would have difficulty meeting their energy demands during exercise, resulting in lethargy and fatigue. Elevated blood-glucose levels (option B) are not expected since PFK deficiency would lead to decreased glucose metabolism. Option A is incorrect since PFK is not required for embryonic development, and option D is unlikely since glycolysis would be impaired, leading to decreased energy production overall.

The Enzyme Phosphofructokinase (PFK) Catalyses a Key Step in Glycolysis