How does the toxin of Vibrio cholerae cause profuse diarrhoea?
A) It modifies a G protein involved in regulating salt and water secretion.
B) It modifies adenylyl cyclase and triggers excess formation of cAMP.
C) It signals IP3 to act as a second messenger for the release of calcium.
D) It modifies a ligand-gated ion channel.

Question

Quizplus · Accepted Answer

The toxin of Vibrio cholerae modifies a G protein, leading to continuous activation of adenylyl cyclase, which increases cAMP levels and causes excessive secretion of water and salts into the intestinal lumen, resulting in diarrhea.

How Does the Toxin of Vibrio Cholerae Cause Profuse Diarrhoea