Cells from advanced malignant tumours often have very abnormal chromosomes and an abnormal number of chromosomes. What might explain the association between malignant tumours and chromosomal abnormalities?
A) Cancer cells are no longer density-dependent.
B) Cancer cells are no longer anchorage-dependent.
C) Cell cycle checkpoints are not in place to stop cells with chromosome abnormalities.
D) Transformation introduces new chromosomes into cells.

Question

Quizplus · Accepted Answer

In normal cells, cell cycle checkpoints ensure that cells with chromosomal abnormalities do not progress to the next stage of the cell cycle. However, cancer cells often lose these checkpoints, allowing cells with abnormal chromosomes to continue to divide uncontrollably, leading to the accumulation of even more chromosomal abnormalities.

Cells from Advanced Malignant Tumours Often Have Very Abnormal Chromosomes