Abnormal chromosomes are frequently found in malignant tumors. Errors such as translocations may place a gene in close proximity to different control regions. Which of the following might then occur to make the cancer worse?
A) an increase in nondisjunction
B) expression of inappropriate gene products
C) a decrease in mitotic frequency
D) death of the cancer cells in the tumor

Question

Quizplus · Accepted Answer

Translocations can result in the expression of inappropriate gene products due to changes in gene regulation. This can contribute to the progression of the cancer, making it worse. Options A, C, and D are not likely to make the cancer worse. An increase in nondisjunction can result in abnormal chromosome numbers in daughter cells, but this may not necessarily affect tumor growth. A decrease in mitotic frequency or death of cancer cells would likely hinder tumor growth, rather than make it worse.

Abnormal Chromosomes Are Frequently Found in Malignant Tumors