A mutation that results in a single amino acid substitution in a region of the enzyme outside of the active site
A) may alter the ability of a competitive inhibitor to bind to the enzyme.
B) will almost always destroy the activity of the enzyme.
C) will often change the substrate specificity of the enzyme.
D) may alter the optimal pH for the enzyme.

Question

Quizplus · Accepted Answer

A single amino acid substitution in a region of the enzyme outside of the active site may alter the three-dimensional structure of the protein, which can result in a change in the optimal pH for the enzyme. However, it is unlikely to destroy the activity of the enzyme, change its substrate specificity, or affect the binding of a competitive inhibitor.

A Mutation That Results in a Single Amino Acid Substitution