Figure 7.1
-If pyruvate oxidation is blocked, what will happen to the levels of oxaloacetate and citrate in the citric acid cycle shown in Figure 7.1?
A) There will be no change in the levels of oxaloacetate and citrate.
B) Oxaloacetate will decrease and citrate will accumulate.
C) Oxaloacetate will accumulate and citrate will decrease.
D) Both oxaloacetate and citrate will decrease.
E) Both oxaloacetate and citrate will accumulate.

Question

Figure 7.1
-If pyruvate oxidation is blocked, what will happen to the levels of oxaloacetate and citrate in the citric acid cycle shown in Figure 7.1?
A) There will be no change in the levels of oxaloacetate and citrate. 
B) Oxaloacetate will decrease and citrate will accumulate. 
C) Oxaloacetate will accumulate and citrate will decrease. 
D) Both oxaloacetate and citrate will decrease. 
E) Both oxaloacetate and citrate will accumulate.

Quizplus · Accepted Answer

Pyruvate oxidation is the step that feeds acetyl-CoA into the citric acid cycle, which is then converted to citrate. If pyruvate oxidation is blocked, acetyl-CoA cannot enter the cycle and the levels of both citrate and oxaloacetate will decrease. However, oxaloacetate can be replenished through anaplerotic reactions, leading to its accumulation, while the decrease in citrate concentration will further inhibit the cycle. As a result, oxaloacetate will accumulate and citrate will decrease.

Figure 7.1 -If Pyruvate Oxidation Is Blocked, What Will Happen to the to the Levels