The beginning of anaphase is indicated by which of the following?
A) loss of kinetochores from sister chromatids
B) enzymatic cleavage of cohesin
C) joining of the sister chromatids to each other by cohesin
D) polymerization of spindle microtubules

Question

Quizplus · Accepted Answer

Enzymatic cleavage of cohesin is necessary for the separation of sister chromatids during anaphase. This allows the two sets of chromosomes to be pulled towards opposite poles of the cell by the spindle fibers. Loss of kinetochores occurs later in anaphase, as the sister chromatids move towards opposite poles. Joining of sister chromatids by cohesin occurs during the S phase of the cell cycle and is important for maintaining the integrity of the chromosome before separation. Polymerization of spindle microtubules occurs throughout the entire cell cycle, but is not specific to anaphase.

The Beginning of Anaphase Is Indicated by Which of the Following