An inactivating mutation in the progesterone receptor gene would likely result in ________.
A) the absence of secondary sex characteristics
B) the absence of pituitary gonadotropin hormones
C) the inability of the uterus to support pregnancy
D) enlarged and hyperactive uterine endometrium
E) the absence of mammary gland development

Question

Quizplus · Accepted Answer

The progesterone receptor plays a crucial role in the maintenance of pregnancy by promoting the growth and differentiation of the uterine lining (endometrium) to support implantation and fetal development. An inactivating mutation in the progesterone receptor gene would result in the inability of the uterus to respond to progesterone signaling, which would ultimately lead to an inability to support pregnancy. The absence of secondary sex characteristics, pituitary gonadotropin hormones, or mammary gland development would likely be caused by mutations in different genes or signaling pathways. An enlarged and hyperactive uterine endometrium would be an unexpected result of an inactivating mutation in the progesterone receptor gene, as the absence of progesterone signaling would lead to reduced endometrial growth and development.

An Inactivating Mutation in the Progesterone Receptor Gene Would Likely