Cells from advanced malignant tumors often have very abnormal chromosomes as well as an abnormal number of chromosomes. What might explain the association between malignant tumors and chromosomal abnormalities?
A) Cancer cells are no longer density dependent.
B) Cancer cells are no longer anchorage dependent.
C) Cell cycle checkpoints are not in place to stop cells with chromosome abnormalities.
D) Chromosomally abnormal cells still have normal metabolism.
E) Transformation introduces new chromosomes into cells.

Question

Quizplus · Accepted Answer

Chromosomal abnormalities can occur when errors in cell replication and division occur, such as when cell cycle checkpoints fail to properly detect and repair DNA damage or errors. Malignant tumors are typically characterized by cells that have highly dysregulated growth and division, which could contribute to the high frequency of chromosomal abnormalities observed in these cells.

Cells from Advanced Malignant Tumors Often Have Very Abnormal Chromosomes