Jacobsen syndrome, which can cause heart defects, intellectual deficiencies, and bleeding disorders, is caused by a deletion of the terminal end of chromosome 11. What method could you use to determine whether an individual has Jacobsen syndrome?
A) Look at a person's skin cells in G1 under a light microscope.
B) Perform a karyotype using a person's white blood cells.
C) Place a person's red blood cells in culture to see if they grow.
D) Count the number of chromosomes present.

Question

Quizplus · Accepted Answer

Performing a karyotype using a person's white blood cells would be the best method to determine whether an individual has Jacobsen syndrome, as the syndrome is caused by a deletion of the terminal end of chromosome 11, which could be detected through chromosome analysis. A karyotype involves arranging an individual's chromosomes in numerical order and examining them for abnormalities or missing segments. This would allow for a definitive diagnosis of Jacobsen syndrome.

Jacobsen Syndrome, Which Can Cause Heart Defects, Intellectual Deficiencies, and Bleeding