ΔG˚′ = -21 kJ/mol for the reaction catalyzed by isocitrate dehydrogenase yet ΔG˚′ = +29.7 kJ/mol for the reaction catalyzed by malate dehydrogenase. Both of these reactions involve the oxidation of a secondary alcoholGive an explanation about why the oxidation of isocitrate is so exergonic.

Question

ΔG˚′ = -21 kJ/mol for the reaction catalyzed by isocitrate dehydrogenase yet ΔG˚′ = +29.7 kJ/mol for the reaction catalyzed by malate dehydrogenase.  Both of these reactions involve the oxidation of a secondary alcoholGive an explanation about why the oxidation of isocitrate is so exergonic.

Quizplus · Accepted Answer

The Answer of ΔG˚′ = -21 kJ/mol for the reaction catalyzed by isocitrate dehydrogenase yet ΔG˚′ = +29.7 kJ/mol for the reaction catalyzed by malate dehydrogenase.  Both of these reactions involve the oxidation of a secondary alcoholGive an explanation about why the oxidation of isocitrate is so exergonic.

ΔG˚′ = -21 KJ/mol for the Reaction Catalyzed by Isocitrate