When phosphorylated, the carboxyl-terminal domain of RNA polymerase II:
A) is insensitive to α-amanitin.
B) enhances transcription.
C) recruits other factors.
D) A and C.
E) B and C.

Question

Quizplus · Accepted Answer

When phosphorylated, the carboxyl-terminal domain (CTD) of RNA polymerase II enhances transcription by promoting interactions with other transcriptional regulators, such as capping enzymes, splicing factors, and histone modifiers. It also recruits other factors, such as mediator and elongation factors, which aid in the elongation of RNA transcripts. However, phosphorylation of the CTD does not affect sensitivity to α-amanitin, which inhibits RNA polymerase II activity regardless of its phosphorylation state.

When Phosphorylated, the Carboxyl-Terminal Domain of RNA Polymerase II