Many different NOD-like receptors, including several with pyrin domains and several with HIN domains, can function to trigger inflammasome assembly leading to the activation of caspase-1. The reason for many different sensors in this innate response system is that:
A) Each NOD-like receptor is expressed in a different set of phagocytic cells, depending on its tissue location.
B) Each NOD-like receptor resides in a different intracellular compartment.
C) Each NOD-like receptor performs a different step in the multi-step cascade leading to inflammasome activation.
D) Each NOD-like receptor binds to a different adapter protein and triggers a different form of the inflammasome.
E) Each NOD-like receptor recognizes different PAMPs and is activated by different pathogens.

Question

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The Answer of Many different NOD-like receptors, including several with pyrin domains and several with HIN domains, can function to trigger inflammasome assembly leading to the activation of caspase-1. The reason for many different sensors in this innate response system is that:
A) Each NOD-like receptor is expressed in a different set of phagocytic cells, depending on its tissue location.
B) Each NOD-like receptor resides in a different intracellular compartment.
C) Each NOD-like receptor performs a different step in the multi-step cascade leading to inflammasome activation.
D) Each NOD-like receptor binds to a different adapter protein and triggers a different form of the inflammasome.
E) Each NOD-like receptor recognizes different PAMPs and is activated by different pathogens.

Many Different NOD-Like Receptors, Including Several with Pyrin Domains and Several