In a mixed lymphocyte reaction, T cells from individual A make a robust response to antigen-presenting-cells from individual B, as long as the two individuals express different alleles of MHC molecules. Estimates indicate that up to 10% of the T cells from individual A may contribute to this response. If one performed this assay using responder T cells from a child and antigen-presenting cells from one parent, the result would be:
A) A massive proliferative response made by the antigen-presenting cells of the parent
B) A very weak response by the child's T cells, involving only 0.1% of their T cells
C) The complete absence of any proliferative response by the child's T cells
D) A robust cytolytic response that kills all of the parent's antigen-presenting cells
E) A robust response by the child's T cells

Question

Quizplus · Accepted Answer

In a mixed lymphocyte reaction, the T cells from individual A will make a robust response to antigen-presenting-cells from individual B, as long as the two individuals express different alleles of MHC molecules. Therefore, when a child’s T cells are used as responder cells and the antigen-presenting cells are from one parent, there is a possibility that the child’s T cells will recognize the differences in the MHC molecules expressed by the parent’s cells, leading to a robust response by the child’s T cells. Hence, the best choice is E - "A robust response by the child's T cells".

In a Mixed Lymphocyte Reaction, T Cells from Individual a Make