Genetically inherited immunodeficiency diseases can result from defects in nearly any component of the immune response. The most severe forms of immunodeficiency occur when T cells are absent or non-functional. An individual with normal B cells, but an absence of T cells might have a defect in:
A) RAG-1 or RAG-2 recombinase proteins
B) Terminal deoxynucleotidyl transferase (TdT)
C) Hematopoietic stem cells
D) Bone marrow stromal cells
E) Thymic stromal cells

Question

Quizplus · Accepted Answer

Thymic stromal cells are responsible for the development and maturation of T cells in the thymus. Without functional thymic stromal cells, T cells cannot develop and therefore, an individual with normal B cells but an absence of T cells might have a defect in thymic stromal cells.

Genetically Inherited Immunodeficiency Diseases Can Result from Defects in Nearly