Match the description in questions with the lettered item (A-I)related to antigen-presentation pathways.
-A protein that binds to newly synthesized class II MHC molecules in the endoplasmic reticulum (ER),which blocks the peptide binding site and directs transport of the class II MHC molecule to endosomes.
A)T cell receptor on CD4+ T cells
B)Endosomes
C)Endoplasmic reticulum
D)Invariant chain
E)Class II-associated invariant chain peptide (CLIP)
F)LMP-2 and LMP-7
G)Acidic proteases
H)T cell receptor on CD8+ T cells
I)HLA-DM

Question

Quizplus · Accepted Answer

The invariant chain prevents peptides generated in the ER from binding to class II MHC,but the invariant chain must be removed in the endosome in order to allow peptides there to bind to the class II MHC.

Match the Description in Questions with the Lettered Item (A-I)related