What happens to T cells whose TCRs are unable to recognize self-MHC complexes?
A)They die within the thymus due to a lack of growth signals.
B)They die within the bone marrow due to a lack of growth signals.
C)They undergo proliferation in the thymus.
D)They undergo proliferation in the bone marrow.
E)They die within the liver due to a lack of growth signals.

Question

Quizplus · Accepted Answer

T cells undergo positive and negative selection in the thymus to ensure that they are able to recognize self-MHC complexes without reacting against self-antigens. If T cells are unable to recognize self-MHC complexes, they do not receive the necessary survival signals and undergo apoptosis within the thymus.

What Happens to T Cells Whose TCRs Are Unable to Recognize