Colchicine has NSAID properties,but also has specific mechanisms including ________ to treat gout.
A) stimulating prostaglandin synthesis and secretion
B) disruption of leukocyte microtubule function, which inhibits cell migration to the site of inflammation
C) activation of xanthine oxidase
D) creating more acidic urine, which increases excretion of uric acid

Question

Quizplus · Accepted Answer

Colchicine works by inhibiting leukocyte microtubule function, which reduces inflammation in the affected joint during a gout attack. This mechanism is independent of the NSAID properties of the drug. Choice A is incorrect because colchicine does not stimulate prostaglandin synthesis and secretion. Choice C is incorrect because xanthine oxidase activation would lead to increased uric acid production and worsen gout symptoms. Choice D is incorrect because colchicine does not affect urine acidity or uric acid excretion.

Colchicine Has NSAID Properties,but Also Has Specific Mechanisms Including ________