Prolyl hydroxylase has all of the following characteristics EXCEPT: A) requires citric acid. B) is activated by Fe²⁺. C) hydroxylates proline residues in proteins. D) requires molecular oxygen. E) requires α-ketoglutarate.

Question

Quizplus · Accepted Answer

Prolyl hydroxylase does not require citric acid. It requires α-ketoglutarate as a co-substrate, molecular oxygen as a co-factor, and Fe2+ or Fe3+ as a co-factor, which can be supplied by Fe²⁺. Prolyl hydroxylase hydroxylates proline residues in proteins, leading to the formation of hydroxyproline.

Prolyl Hydroxylase Has All of the Following Characteristics EXCEPT