How does extracellular hormone binding activate intracellular tyrosine kinase activity?
A) conformational change induced active site activation
B) conformational change induced oligomeric association and phosphorylation
C) induced mRNA synthesis
D) activation of specific phospholipases
E) all are true

Question

Quizplus · Accepted Answer

When the extracellular hormone binds to the receptor, this causes a conformational change that results in the oligomeric association of the receptors. This association then leads to auto-phosphorylation of tyrosine kinase domains within the cytoplasmic region of the receptor, leading to its activation. This activation then initiates a signaling cascade of downstream effectors, ultimately resulting in a cellular response.

How Does Extracellular Hormone Binding Activate Intracellular Tyrosine Kinase Activity