How would one carry out the following transformation? A)NaNO₂,HCl,0-5 $\circ$ C; then HNO₃ B)NaNO₂,HCl,0-5 $\circ$ C; then H₃PO₂ C)NaNO₂,HCl,0-5 $\circ$ C; then H₂,Ni D)C₆H₅SO₂Cl,OH^-; then HCl E)NaH,DMSO

Question

Quizplus · Accepted Answer

The transformation requires replacing the TB5902_00 part with H₃PO₂. This can be achieved by treating the compound with NaNO₂, HCl, 0-5 F1F1F1S1F1F1F10C to remove the TB protecting group and then adding H₃PO₂ as the new protecting group using standard solid-phase peptide synthesis methods. The other answer choices are not relevant for this transformation.

How Would One Carry Out the Following Transformation? A)NaNO2,HCl,0-5 ∘\circ∘

How Would One Carry Out the Following Transformation?
A)NaNO₂,HCl,0-5 $\circ$