What effects would increased circulating levels of glucocorticoids have on the pituitary secretion of ACTH?
A)They would inhibit the release of CRH which would reduce the secretion of ACTH.
B)They would inhibit the release of CRH which would stimulate the secretion of ACTH.
C)They would stimulate the release of CRH which would reduce the secretion of ACTH.
D)They would stimulate the release of CRH which would stimulate the secretion of ACTH.
E)They would inhibit the release of cortisol which would stimulate the secretion of ACTH.

Question

Quizplus · Accepted Answer

Increased levels of glucocorticoids would provide a negative feedback to the hypothalamus, causing a reduction in the release of CRH (corticotropin-releasing hormone). With reduced CRH, the secretion of ACTH (adrenocorticotropic hormone) by the pituitary gland would also decrease. This is a classic example of the hypothalamic-pituitary-adrenal (HPA) axis feedback loop regulation.

What Effects Would Increased Circulating Levels of Glucocorticoids Have on the Pituitary