Thiamine deficiency results in accumulation of which of the following metabolites in the blood?
A) citrate
B) glycerol
C) pyruvate
D) glucose
E) carbon dioxide

Question

Quizplus · Accepted Answer

Thiamine (vitamin B1) is a cofactor for the enzyme pyruvate dehydrogenase, which converts pyruvate to acetyl-CoA as part of the aerobic respiration pathway. Thiamine deficiency leads to decreased activity of pyruvate dehydrogenase, resulting in an accumulation of pyruvate in the blood. This can lead to impaired glucose metabolism and decreased energy production in cells. Citrate, glycerol, glucose, and carbon dioxide are not directly affected by thiamine deficiency.

Thiamine Deficiency Results in Accumulation of Which of the Following