Which statement about the Cori cycle is TRUE?
A) All of the component reactions occur in the liver.
B) Lactate from muscle is used in the liver as a gluconeogenic substrate.
C) Free glucose, produced from glycogen in skeletal muscle, is utilized for the synthesis of glycogen in the liver.
D) It is the cycle in the liver by which glycogen is synthesized from and degraded to glucose 1-phosphate.
E) All of the component reactions occur in skeletal muscle.

Question

Quizplus · Accepted Answer

The Cori cycle involves the conversion of lactate produced by muscles during aerobic glycolysis into glucose via gluconeogenesis in the liver. This glucose can then be transported back to the muscles to be used as a fuel source. Therefore, lactate from muscle is used in the liver as a gluconeogenic substrate.

Which Statement About the Cori Cycle Is TRUE