Which statement regarding citrate in mammalian metabolism is FALSE?
A) It activates fatty acid synthesis.
B) It activates the pyruvate dehydrogenase complex.
C) It inhibits glycolysis at the step catalyzed by phosphofructokinase.
D) It is a source of acetyl-CoA for fatty acid synthesis.
E) It may be used in the Krebs cycle for production of energy.

Question

Quizplus · Accepted Answer

Citrate inhibits the pyruvate dehydrogenase complex rather than activating it. This enzyme complex is responsible for converting pyruvate into acetyl-CoA, a crucial step linking glycolysis and the Krebs cycle. Citrate's role in metabolism includes activating fatty acid synthesis, inhibiting glycolysis at the phosphofructokinase step, serving as a source of acetyl-CoA for fatty acid synthesis, and participating in the Krebs cycle for energy production, but not activating the pyruvate dehydrogenase complex.

Which Statement Regarding Citrate in Mammalian Metabolism Is FALSE