Why do tumors tend to use glycolysis as the source of most of their ATP?
A) Angiogenesis delivers a large amount of glucose
B) Lack of oxygen induces HIF-1a
C) These cells have fewer mitochondria
D) These cells do not have enzymes of electron transport
E) These cells do not have TCA enzymes

Question

Quizplus · Accepted Answer

Lack of oxygen induces HIF-1a, which upregulates glycolysis and downregulates oxidative phosphorylation. Tumors often have an insufficient blood supply, leading to hypoxia and HIF-1a activation, promoting glycolysis as the primary source of ATP.

Why Do Tumors Tend to Use Glycolysis as the Source