In skeletal muscle during strenuous exercise, the NADH produced in the reaction catalyzed by glyceraldehyde 3- phosphate dehydrogenase is reoxidized primarily by
A) malate dehydrogenase.
B) lactate dehydrogenase.
C) pyruvate dehydrogenase.
D) isocitrate dehydrogenase.
E) glucose 6-phosphate dehydrogenase.

Question

Quizplus · Accepted Answer

During strenuous exercise, the oxygen availability to tissues decreases, leading to anaerobic conditions where the pyruvate produced from glycolysis is converted to lactate. This process is catalyzed by lactate dehydrogenase, which regenerates NAD+ by oxidizing NADH. This allows for continued glycolysis to produce ATP to power muscle contractions. Therefore, the NADH produced in the reaction catalyzed by glyceraldehyde 3-phosphate dehydrogenase is reoxidized primarily by lactate dehydrogenase.

In Skeletal Muscle During Strenuous Exercise, the NADH Produced in the Reaction