All of the following metabolic conditions favor the conversion of pyruvate to glucose EXCEPT
A) an active form of pyruvate carboxylase.
B) a rapid rate of fatty acid oxidation.
C) an energy charge near 1.0.
D) a low level of active phosphoenolpyruvate carboxykinase.
E) an inhibited pyruvate dehydrogenase complex.

Question

Quizplus · Accepted Answer

The conversion of pyruvate to glucose is a process known as gluconeogenesis. For gluconeogenesis to proceed efficiently, enzymes that catalyze the conversion steps must be active. Pyruvate carboxylase and phosphoenolpyruvate carboxykinase (PEPCK) are two key enzymes in this pathway. A low level of active PEPCK (choice D) would hinder the conversion of pyruvate to glucose, making it the correct exception. The other options either directly support gluconeogenesis or create conditions that favor the conservation of glucose or its synthesis from precursors like pyruvate.

All of the Following Metabolic Conditions Favor the Conversion of Pyruvate