Two enzymes specifically required for gluconeogenesis from lactate but not from glycerol are
A) pyruvate kinase and phosphoglycerate kinase.
B) pyruvate carboxylase and phosphoenolpyruvate carboxykinase.
C) glucose 6-phosphate dehydrogenase and phosphoenolpyruvate carboxykinase.
D) fructose 1,6-bisphosphatase and phosphofructokinase-1.
E) glyceraldehyde 3-phosphate dehydrogenase and aldolase.

Question

Quizplus · Accepted Answer

Pyruvate carboxylase and phosphoenolpyruvate carboxykinase are the two enzymes specifically required for gluconeogenesis from lactate but not from glycerol. Pyruvate carboxylase converts pyruvate to oxaloacetate, which is then converted to phosphoenolpyruvate by phosphoenolpyruvate carboxykinase. Glycerol can be converted to dihydroxyacetone phosphate and enter glycolysis or gluconeogenesis at a later stage, so these enzymes are not required for gluconeogenesis from glycerol.

Two Enzymes Specifically Required for Gluconeogenesis from Lactate but Not