High concentrations of substrate overcome reversible inhibition by a transition-state analog because
A) only the substrate has the inherent ability to bind at the active-site.
B) the substrate has a greater inherent affinity for the active-site.
C) transition-state analogs show noncompetitive kinetics.
D) the substrate will react with the transition-state analog.
E) The transition-state analog is a competitive inhibitor.

Question

Quizplus · Accepted Answer

The transition-state analog is a competitive inhibitor, meaning it competes with the substrate for binding at the active site. High concentrations of substrate can outcompete the inhibitor for binding, overcoming the inhibition.

High Concentrations of Substrate Overcome Reversible Inhibition by a Transition-State