Which of the following factors can be significant in enzyme catalysis?
A) induced fit
B) distortion or strain in the substrate
C) general acid-base catalysis
D) covalent catalysis
E) all of the above are correct

Question

Quizplus · Accepted Answer

All of these factors can be important in enzyme catalysis. Induced fit refers to the conformational changes that occur in the enzyme upon substrate binding, which can help align catalytic residues with the substrate. Distortion or strain in the substrate can facilitate bond breaking or formation, allowing the reaction to proceed more easily. General acid-base catalysis involves the transfer of protons to or from the substrate or intermediates, which can stabilize or destabilize charged species and facilitate reactions. Covalent catalysis involves the formation of a covalent intermediate between the enzyme and substrate, which can alter the reaction pathway and lower the activation energy.

Which of the Following Factors Can Be Significant in Enzyme