An enzyme transition state inhibitor
A) would probably bind much more tightly than a normal substrate.
B) probably would be a noncompetitive inhibitor of an enzyme.
C) would probably bind much less tightly than a normal substrate.
D) would have a Ki about equal to the Km for the substrate.

Question

Quizplus · Accepted Answer

Enzyme transition state inhibitors are designed to mimic the transition state of the enzyme-catalyzed reaction, which is a high-energy intermediate state. Therefore, they are expected to bind much more tightly to the enzyme active site than the substrate itself. This is important because the tight binding of the inhibitor prevents the substrate from accessing the active site and performing the reaction.

An Enzyme Transition State Inhibitor