Generation of antibody diversity is primarily caused by
A) Covalent modification of immunoglobulin proteins.
B) Differences in splicing of the primary RNA transcripts of antibody genes.
C) Rearrangement of DNA.
D) DNA recombination in response to particular antigens.
E) Specific folding of antibody-combining sites induced by particular antigens.

Question

Quizplus · Accepted Answer

Antibody diversity is primarily caused by the rearrangement of DNA during B cell development. This process is known as V(D)J recombination and involves the shuffling of different gene segments encoding the variable regions of an antibody to create millions of possible combinations.

Note: Choices A, B, D, and E are not correct because they do not accurately describe the primary mechanism for antibody diversity generation.

Generation of Antibody Diversity Is Primarily Caused by