Proteins synthesized in the cytosol require GTP as part of the nuclear transport process. Which step in this process requires the GTP?
A) Formation of nuclear pore
B) Interaction with carrier protein
C) Refolding of protein in nucleus
D) Return of carrier protein to cytosol
E) Transport through the pore

Question

Quizplus · Accepted Answer

GTP is required for the return of the carrier protein (often referred to as importins and exportins) to the cytosol after it has transported its cargo (e.g., a protein) into the nucleus. This step involves the hydrolysis of GTP, which provides the energy necessary for the carrier protein to release its cargo within the nucleus and return to the cytosol for another round of transport.

Proteins Synthesized in the Cytosol Require GTP as Part of the Nuclear