The nucleosome is the basic repeating unit of chromatin. Which of the following statements concerning nucleosomes is incorrect?
A) Nucleosomes have protein cores consisting of an octamer of protein subunits.
B) A segment of DNA approximately 145 bp long is associated with each nucleosome.
C) Histone H1 contacts the DNA linker segments as they enter and leave the nucleosome.
D) The DNA in a nucleosome is packed tightly inside the protein core to conserve space in the nucleus and to protect the DNA from damage.
E) Some nucleosomes form over specific regions of DNA in a non-random manner.

Question

Quizplus · Accepted Answer

The statement "The DNA in a nucleosome is packed tightly inside the protein core to conserve space in the nucleus and to protect the DNA from damage" is incorrect. While the DNA is indeed compacted, it is not packed tightly inside the protein core, but rather wrapped around it in a loose manner. This allows for access to the DNA when needed for processes such as gene expression.

The Nucleosome Is the Basic Repeating Unit of Chromatin