A one nucleotide slip in the splice point on the side of the splice junction in the first intron of the beta-globin gene would result in
A) changing the reading frame of the mRNA from this point onward.
B) deletion of the rest of the beta-globin gene.
C) no change in the protein as all coding information is 5' to this junction.
D) a transition mutation.
E) a transversion mutation.

Question

Quizplus · Accepted Answer

A one nucleotide slip in the splice point on the side of the splice junction in the first intron of the beta-globin gene would shift the reading frame of the mRNA, resulting in a different sequence of amino acids in the encoded protein. This is known as a frameshift mutation. This change can have significant consequences for the structure and function of the protein.

A One Nucleotide Slip in the Splice Point on the Side