Which of the following peptides would be least soluble in aqueous solution?
A) Val - Arg - His - Ser - Glu - Arg - Tyr - Asp
B) Val - Gly - Pro - Ser - Gly - Lys - Pro - Gly
C) Val - Leu - Gly - Ser - Gly - Leu - Phe - Val
D) Val - Arg - Cys - Ser - Glu - Glu - Cys - Glu

Question

Quizplus · Accepted Answer

Peptide C has a higher proportion of hydrophobic amino acids (Val, Leu, Phe) compared to the other peptides, making it less soluble in aqueous solution. Hydrophobic amino acids tend to avoid water, thus reducing the solubility of the peptide in water.

Which of the Following Peptides Would Be Least Soluble in Aqueous