A protein whose isoelectric point is 5.3 will exhibit minimum solubility at pH
A) 3.3
B) 4.3
C) 5.3
D) 6.3
E) 7.3

Question

Quizplus · Accepted Answer

The isoelectric point (pI) is the pH at which a protein has a net charge of zero. At pH values below the pI, the protein is positively charged, and at pH values above the pI, the protein is negatively charged. Therefore, when the pH is close to the pI, the protein is least soluble because it lacks a net charge and cannot form a stable solvation shell. In this case, the protein's pI is 5.3, so the pH at which it will exhibit minimum solubility is also 5.3.

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