Which one of the following factors is considered to be the major force which leads to conformational stability of globular proteins?
A) hydrogen bonding.
B) hydrophobic interactions.
C) ionic interactions.
D) disulfide bonding.
E) van der Waals forces.

Question

Quizplus · Accepted Answer

Hydrophobic interactions are considered the major force which leads to conformational stability of globular proteins. This is because hydrophobic amino acid residues tend to be buried within the protein core to avoid contact with water, leading to a more stable protein structure. The other factors (hydrogen bonding, ionic interactions, disulfide bonding, and van der Waals forces) also contribute to protein stability but are typically considered secondary to hydrophobic interactions.

Which One of the Following Factors Is Considered to Be