The term denaturation, when used in connection with nucleic acids or proteins refers to a change in structural characteristics due to
A) the disruption of covalent bonds.
B) the disruption of non-covalent bonds.
C) the binding of toxic compounds.
D) changes in primary structure.
E) changes in the state of aggregation.

Question

Quizplus · Accepted Answer

Denaturation involves the disruption of non-covalent bonds, such as hydrogen bonds and van der Waals interactions, which lead to changes in the structure of nucleic acids or proteins. These changes can result in loss of function or activity. Disruption of covalent bonds would result in a completely different molecule, whereas changes in primary structure refer to alterations in the sequence of amino acids or nucleotides. Binding of toxic compounds may cause denaturation, but it is not the defining characteristic of this process. Changes in the state of aggregation refer to physical changes in the organization of molecules, which may or may not be related to denaturation.

The Term Denaturation, When Used in Connection with Nucleic Acids