The mutation resulting in sickle cell disease changes one base pair of DNA so that a codon now codes for a different amino acid, making it an example of a ________.
A) nonsense mutation
B) frameshift mutation
C) silent mutation
D) missense mutation

Question

Quizplus · Accepted Answer

The mutation resulting in sickle cell disease changes one base pair of DNA so that a codon now codes for a different amino acid, making it a missense mutation. A nonsense mutation involves a change of a single nucleotide that creates a premature stop codon, resulting in early termination of translation. A frameshift mutation involves the insertion or deletion of nucleotides, causing a shift in the reading frame of the codons, resulting in a completely different amino acid sequence from the original. A silent mutation involves a change in the DNA sequence that does not result in a change in the amino acid sequence due to the redundancy of the genetic code.

The Mutation Resulting in Sickle Cell Disease Changes One Base