Tetrodotoxin blocks voltage-gated sodium channels and ouabain blocks sodium-potassium pumps. If you added both tetrodotoxin and ouabain to a solution containing neural tissue, what responses would you expect?
A) immediate loss of resting potential
B) immediate loss of action potential with gradual loss of resting potential
C) slow decrease of resting potential and action potential amplitudes
D) No effect; the substances counteract each other.

Question

Quizplus · Accepted Answer

Tetrodotoxin blocks voltage-gated sodium channels, preventing the generation of action potentials, resulting in an immediate loss of action potential. Ouabain blocks sodium-potassium pumps, leading to a gradual loss of resting potential. Therefore, in the given scenario, the immediate loss of action potential with gradual loss of resting potential would be expected.

Tetrodotoxin Blocks Voltage-Gated Sodium Channels and Ouabain Blocks Sodium-Potassium Pumps