Targeted mutation in mice that prevented the production of insulin receptors in the brain without affecting their production elsewhere in the body resulted in mice that
A) experienced diabetes.
B) lose a great deal of weight.
C) showed behavior similar to post traumatic stress.
D) maintained body weight for an extended period of time.
E) became obese.

Question

Quizplus · Accepted Answer

Insulin receptors in the brain are crucial for regulating energy balance and body weight. When these receptors are absent or non-functional in the brain, the body's ability to regulate energy intake and expenditure is disrupted, often leading to obesity. This is because insulin signaling in the brain affects hunger and satiety signals, as well as how energy is stored and used throughout the body.

Targeted Mutation in Mice That Prevented the Production of Insulin